Designing and Developing a New Generation of Biotherapeutics
Sutro Biopharma's scalable biochemical protein synthesis technology platform enables the design and production of protein therapeutics and biosuperiors that cannot be produced with other technologies. The technology platform unlocks new therapeutic opportunities through a unique synthesis approach and the introduction of site-specific chemical modifications, including non-natural amino acids, to improve therapeutic performance.
Conventional methods for expressing proteins depend on utilizing living cell lines that originate from bacteria, yeast, insects, plants, or mammals. These cell-based technologies exhibit several limitations in respect to synthesis of proteins, including those with novel chemical modifications, and many biologics can't be developed in these systems.

Sutro's technology enables:

• The synthesis of many therapeutic proteins and families of proteins that have been inaccessible using current cellular expression technologies.
• Rapid and predictable combinatorial expression optimization.
• Linearly scalable production of hundreds of liters: direct, fast and predictable advancement from bench to GMP production.
• Accelerated development cycles with a single master cell bank for any protein produced using readily available microbial manufacturing capacity for volume production.
• The rapid incorporation of a wide variety of non-natural amino acid side chains, leading to optimization of protein properties in a combinatorial fashion.

Sutro's protein synthesis technology focuses all biochemical reactions to make one protein.

Sutro's technology has been designed to promote proper folding by optimizing synthesis and the chemical and physical environment to maintain homeostasis throughout the expression process. The components of the system have been selected to closely mimic the environment of the cellular folding compartment. In addition, the open architecture of the system easily allows additions of exogenous chemical species as well as catalysts to promote folding in the cases where those additions are needed.