Changing the future of Oncology.
In September, 2014, Sutro announced a $300M+ collaboration with Merck KGaA, Darmstadt, Germany (also known as EMD Serono) discover and develop novel antibody drug conjugates for several targets in the field of oncology.
M1231 was generated using Sutro’s XpressCF® and Sutro’s XpressCF+™ cell-free protein synthesis and conjugation technologies and includes a Sutro proprietary linker-warhead. The ADC is based on Merck KGaA, Darmstadt, Germany’s strand-exchange engineered domain (SEED) antibody platform. As part of the agreement, Sutro is manufacturing the antibody and linker-warhead for the early clinical supply and is eligible for further payments and tiered royalties ranging from low to mid-single digit percentages, along with certain additional one-time royalties, on worldwide sales of any commercial products that may result from the collaboration. Merck KGaA, Darmstadt, Germany will be responsible for drug product, clinical development and, upon regulatory approval, the commercialization of this product candidate.