News

Computational Chemist

March 11, 2019

Sutro Biopharma is seeking a highly qualified computational chemist to build a structure-based drug design (SBDD) platform for our emerging medicinal chemistry team and to apply molecular modeling and computational chemistry techniques toward the advancement of our small-molecule drug discovery programs. The successful candidate will closely work together with our medicinal chemistry team to apply structure and ligand-based in silico methods to design molecules in support of all aspects of small molecule drug discovery ranging from lead identification to candidate selection.

Key Responsibilities

  • Serve as a lead computational chemist on several drug discovery projects and build a SBDD and modeling infrastructure to be implemented as an integrative component of our small molecule design projects.
  • Partner with multidisciplinary and highly collaborative discovery teams to optimize/accelerate the development of novel drug candidates using advanced computational techniques.
  • Support drug discovery projects by combining a deep understanding of theory and medicinal chemistry concepts with cutting-edge computational tools.
  • Enhance our understanding of SAR from Ro5 and beyond Ro5 projects and influence the team strategy by generating and interpreting data using appropriate modeling techniques.
  • Engage in virtual screening campaigns and in the development of pharmacophore models.
  • Apply a variety of drug-design and computational chemistry methods to improve potency, selectivity, and ADME properties of lead compounds.
  • Perform molecular dynamics simulations and build testable hypotheses regarding drug binding, SAR, and computational biophysics.
  • Integrate data across multiple research disciplines to help shape medicinal chemistry strategy as projects develop.
  • Maintain and develop working knowledge of contemporary computational chemistry methods and their use in ligand design and data analysis as applied to drug designs.
  • Participate in interdisciplinary teams and external collaborators.

Education & Experience

  • The position requires a PhD in computational chemistry or related discipline with 10+ years in the biotech/pharmaceutical industry.
  • Advanced knowledge of medicinal and computational chemistry principles and knowledge of how to apply these techniques to drug discovery projects.
  • Practical experience in structure-based drug design, including docking, homology modeling, molecular dynamics simulation, and free energy calculation; ligand-based drug design, including pharmacophore modeling, QSAR, 3D-QSAR, pharmacophore- or shape-based database searching, combinatorial library design, and target focused library construction.
  • Specifically, a working knowledge of state-of-the-art modeling and cheminformatics suites such as those from Schrodinger, MOE, OpenEye, or ChemAxon, experience with docking tools such as Glide, GOLD or DOCK, and experience with data visualization & analysis tools like Vortex or Spotfire.
  • A proven record of scientific leadership and innovation as demonstrated by publications, presentations, and / or patents.
  • Excellent communication and organizational skills are required.

Sutro provides a competitive benefits package that includes a choice of health, dental, and vision insurance, life insurance, flexible spending accounts, 401K plan, PTO, and stock options.

Please submit resume for Req. #1911 to jobs@sutrobio.com. Please visit our website at www.sutrobio.com for more information.  Local Candidates, SF Bay Area.