Scientist, Upstream Process Development

Jul 16, 2020

You will participate in cross-functional teams and collaborate on multiple projects. Responsibilities include ensuring the smooth operation of Sutro’s novel cell-free protein synthesis process (XpressCF™), optimizing cell-free expression conditions for product candidates in various stages of development from lead optimization through GMP manufacturing, and working with multiple groups in R&D to improve product titers and product quality by examining the biochemical and physical factors affecting cell-free performance and scale-up. Experiments are conducted over a large range of scales using a variety of techniques, including high throughput screening and large scale (kL) production. Work may also include technology transfer to internal and external Manufacturing sites.


The successful candidate will design and execute cell-free protein synthesis processes and develop new processes appropriate to the scale and manufacturing phase for given projects. Two major foci of the position will be expanding the biochemical understanding of XpressCF™ and improving process performance for both titer and product quality. In addition, the successful candidate will be required to make presentations to internal teams and senior management and to author internal and external publications.


We are seeking a highly motivated team-player with excellent problem-solving skills and experience with bioprocesses and microbial metabolism. Versatility is a must, as tasks will involve a range of reactors and scales and process modes. Good organizational skills and the ability to manage tasks within a timeline are essential.

The ideal candidate will have the following background/skill set:

  • Ph.D. with 0-5 years industry experience or M.S. with 5-10 years’ experience in Chemical Engineering, Bioengineering, Biochemistry, or a related discipline

Experience with the following is required:

  • laboratory scale process equipment, especially bioreactors for microbial and/or mammalian culture
  • bioprocess development (cell-free, microbial, and/or mammalian cell-based)

Experience with the following is preferred:

  • cell-free protein synthesis
  • metabolite/biochemical assays (HPLC and/or microtiter plate based)
  • Design of Experiments
  • cGMP bioprocessing

Please submit resume for Req. #2042 to Please visit our website at for more information. Local candidates, SF Bay Area.

Sutro provides a competitive benefits package that includes a choice of health, dental, and vision insurance, life insurance, flexible spending accounts, 401K plan, PTO, ESPP (Employee Stock Purchase Plan) and stock options. 

Sutro Biopharma is committed to the diversity of our team and we are committed to Equal Employment Opportunity without regard for race, ethnicity, gender, protected veteran status, disability, sexual orientation, gender identity or religion.

Salaries listed on jobsites may not be representative of salary ranges at Sutro Biopharma.

Please be advised, inquiries or resumes from recruiters will not be accepted.