Senior Scientist, Upstream Process Development (South San Francisco, CA)

Sutro Biopharma, Inc. is looking for a Senior Scientist of Upstream Process Development who will participate in cross-functional teams and collaborate on multiple projects. Responsibilities include ensuring the smooth operation of Sutro’s novel cell-free protein synthesis process (XpressCF™), optimizing cell-free expression conditions for product candidates in various stages of development from lead optimization through GMP manufacturing, and working with multiple groups in R&D to improve product titers and product quality by examining the biochemical and physical factors affecting cell-free performance and scale-up. This position will support candidate product projects as they move through clinical trials including late-stage development work and possibly commercialization. Experiments are conducted over a large range of scales using a variety of techniques, including high throughput screening and large scale (kL) production. Work may also include technology transfer to internal and/or external manufacturing sites. This position will also collaborate with the Platform Technology PD group to expand our knowledge base on cell-free protein synthesis.


The successful candidate will design and execute cell-free protein synthesis processes and develop new processes appropriate to the scale and manufacturing phase for given projects. You will also contribute to late-stage process development efforts including documentation to support regulatory filings. In addition, the successful candidate will be required to make presentations to internal teams and senior management and to author internal and external publications.


We are seeking a highly motivated team-player with excellent problem-solving skills and experience with bioprocesses and microbial metabolism. Versatility is a must, as tasks will involve a range of reactors and scales and process modes. Good organizational skills and the ability to manage tasks within a timeline are essential. 

The ideal candidate will have the following background/skill set: 

  • Ph.D. with 5 or more years industry experience or M.S./B.S. with 10 or more years of experience in Chemical Engineering, Bioengineering, Biochemistry, or a related discipline.

Experience with the following is required:

  • Laboratory scale process equipment, especially bioreactors for microbial and/or mammalian culture.
  • Late-stage bioprocess development (cell-free, microbial, and/or mammalian cell-based)

Experience with the following is preferred:

  • Cell-free protein synthesis.
  • Metabolite/biochemical assays (HPLC and/or microtiter plate based).
  • Design of Experiments.
  • cGMP bioprocessing.

Sound exciting? Apply today and join our team! 

Please submit resume for Req. #2253 to Please visit our website at for more information.

Sutro provides a competitive benefits package that includes a choice of health, dental, and vision insurance, life insurance, flexible spending accounts, 401K plan, PTO, ESPP (Employee Stock Purchase Plan) and stock options.

As an equal opportunity employer, we believe in fostering a culture that is inclusive and values diversity in background and opinions. Sutro Biopharma hires extraordinary individuals into every position in the company and is committed to the diversity of our team. Our company progresses without regard of race, ethnicity, gender, sexual orientation, religious belief, age, disability or citizenship status. We are dedicated to creating a safe environment where our employees can grow and succeed together. 

Salaries listed on jobsites may not be representative of salary ranges at Sutro Biopharma.

Please be advised, inquiries or resumes from recruiters will not be accepted.

Company Overview 

Sutro Biopharma, Inc., located in South San Francisco, is a clinical-stage drug discovery, development and manufacturing company. Using precise protein engineering and rational design, Sutro is advancing next-generation oncology therapeutics.

Sutro is dedicated to transforming the lives of cancer patients by creating medicines with improved therapeutic profiles for areas of unmet need. To date, Sutro’s platform has led to cytokine-based immuno-oncology therapies, ADCs, vaccines and bispecific antibodies directed at precedented targets in clinical indications where the current standard of care is suboptimal.

The platform allows it to accelerate discovery and development of potential first-in-class and best-in-class molecules through rapid and systematic evaluation of protein structure-activity relationships to create optimized homogeneous product candidates.

In addition to developing its own oncology pipeline, Sutro is collaborating with select pharmaceutical and biotech companies to discover and develop novel, next-generation therapeutics. As the pace of clinical development accelerates, Sutro and its partners are developing therapeutics designed to more efficiently kill tumors without harming healthy cells.