Differentiated Pipeline of Single- and Dual Payload ADCs

We are at the forefront of next-generation ADCs and, through our cell-free platform, we have fully optimized the antibody, linker, and payload to expand the therapeutic window, minimizing toxicity and maximizing efficacy.

We are advancing multiple candidates in parallel to address large market opportunities. Our single-payload ADCs, STRO-004 and STRO-006, are designed with best-in-class potential for complex targets across multiple tumor types where competition remains limited. Our dual-payload ADC programs represent a new class of supercharged ADCs designed to overcome resistance and delay disease progression. By combining distinct payloads, these programs have the potential to deliver improved clinical benefit, tolerability, and durability of response.

Proprietary Programs

PROGRAM
MODALITY/
TARGET
INDICATION
DISCOVERY
PRECLINICAL
PHASE 1/1B
PHASE 2
PHASE 3/
REGISTRATIONAL
INFO
STRO-004
Tissue Factor ADC
Solid Tumors

STRO-006
Integrin αvβ6
Solid Tumors
STRO-227
PTK7 Dual-Payload ADC
Solid Tumors
STRO-00Y
Dual-Payload ADC
Solid Tumors

Partnered Programs

PROGRAM
MODALITY/
TARGET
INDICATION
DISCOVERY
PRECLINICAL
PHASE 1/1B
PHASE 2
PHASE 3/
REGISTRATIONAL
PARTNERS
VAX-31
31-Valent Conjugate Vaccine
Invasive Pneumococcal Disease
VAX-24
24-Valent Conjugate Vaccine
Invasive Pneumococcal Disease
ASP2998
TROP2-targeted Immunostimulatory ADC (iADC)
Cancers
UNDISCLOSED
PROGRAM
iADC
Cancer

Clinical Trials

Patients are Sutro’s passion and purpose. Our ongoing clinical trials represent our commitment to delivering new, life-changing therapies to people who need them most. Interested in learning more? Explore our clinical trials below.

STRO-004 | Tissue Factor

A Phase 1 Open-Label Study to Evaluate Safety, Pharmacokinetics, and Preliminary Anti-Tumor Activity of STRO-004 in Adults With Refractory/Recurrent Metastatic Solid Tumors.

For questions, please contact us at patients@sutrobio.com

Sutro Biopharma, Inc.
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