Clinical Trial




STRO-002-GM1 is a FolRa targeting ADC for the potential treatment of ovarian and endometrial cancer

  • STRO-002-GM1 is currently in an ongoing first-in-human, phase 1, open-label, multicenter, dose expansion study evaluating the safety, tolerability and preliminary anti-tumor activity of STRO-002-GM1 in adults with ovarian cancer.
  • STRO-002 was granted Fast Track designation by the U.S. Food and Drug Administration (FDA) in August, 2021 for the treatment of patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received one to three prior lines of systemic therapy.

STRO-002-GM1 is a novel homogeneous antibody drug conjugate using precisely positioned non-natural amino acids

  • STRO-002-GM1 targets the tumor cell carrying four cytotoxins, these are proprietary cleavable hemiasterlin linker-warheads (DAR=4) that are stable in circulation
  • The active warhead is internalized by the tumor cell, efficiently killing them in a manner that can stimulate the immune system, an effect called immunogenic cell death.[1]

For more information about this trial, visit

[1]Source: June 22, 2020 AACR 2020 Virtual Meeting II – Abstract 

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